If I'm understanding correctly, it sounds like you wanna be able to run different afr in different areas of engine operation. And yes the Holley and others like it can easily do that. What can potentially help driveability (and mileage) as much or more, is the ability to run a non linear ignition curve, if using the timing control features.
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'65 Tempest 467 3650# 11.30@120.31
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