It's not just the stoich that changes, your timing requirements will also change. I find when I tune EFI flex cars I need to pull timing out in the mid range (around 4-6 degrees) all the way to the top otherwise the knock sensors start working or you can hear it rattling when driving through a tunnel etc...
Just something to look at if you're wanting to use E10. BTW all of my cars are flex because I run E10 in everything. It is such a good fuel for the $$$. Even my fuel injected 400 Pontiac. It loves it! My turbo LS3, just cap the boost at about 7-8psi and it'll turn about 550hp wheel on e10 but will go 635 on non-ethanol 98 fuel (93 over there) on 10psi. On e85 it should go around 800 wheel at 13psi.
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'71 Holden HQ Monaro - 3850lbs race weight, 400c/i - 11.4 @ 120
'66 Pontiac GTO - 389, 4 speed street cruiser
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